Tetanus toxin: Difference between revisions
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[[Image:Mechanism_of_action_of_tetanospasmin.jpg|thumb|350px|left|Mechanism of Action for Tetanospasmin.<ref> Mechanism of Action of Tetanospasmin (Dr. Arnab K Rana) [image on the internet]. 2005[updated 2005 Dec 26; cited 2011 Apr 20]. Available from: http://en.wikipedia.org/wiki/File:Mechanism_of_action_of_tetanospasmin.gif</ref>]] | [[Image:Mechanism_of_action_of_tetanospasmin.jpg|thumb|350px|left|Mechanism of Action for Tetanospasmin.<ref> Mechanism of Action of Tetanospasmin (Dr. Arnab K Rana) [image on the internet]. 2005[updated 2005 Dec 26; cited 2011 Apr 20]. Available from: http://en.wikipedia.org/wiki/File:Mechanism_of_action_of_tetanospasmin.gif</ref>]] | ||
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== Retrograde Axonal Transport == | == Retrograde Axonal Transport == | ||
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[[Image:TeNT.jpg|thumb|200px|left|An overlap of three copies of the TeNT Hc structure. This image helps to illustrate the two separte and distinct domains of the Hc fragment of tetanospasmin.<ref name="hcfrag" />]] | [[Image:TeNT.jpg|thumb|200px|left|An overlap of three copies of the TeNT Hc structure. This image helps to illustrate the two separte and distinct domains of the Hc fragment of tetanospasmin.<ref name="hcfrag" />]] | ||
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Hc has two distinct domains:<ref name="hcfrag"> PMID:11418600</ref> | Hc has two distinct domains:<ref name="hcfrag"> PMID:11418600</ref> | ||
[[Image:GT1-b ganglioside.jpg|thumb|350px|right|Ganglioside GT1-b.<ref name="hcfrag" />]] | [[Image:GT1-b ganglioside.jpg|thumb|350px|right|Ganglioside GT1-b.<ref name="hcfrag" />]] | ||
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1. Jelly-roll (amino end) | 1. Jelly-roll (amino end) | ||
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[[Image:GT1-b Ana.jpg|thumb|350px|right|GT1-b analogue which was used to bind to the Hc fragment in this study. The analogue differs from the native GT1-b in that Sia6 is the β-anomer and the ceramide group has been replaced.<ref name="hcfrag" />]] | [[Image:GT1-b Ana.jpg|thumb|350px|right|GT1-b analogue which was used to bind to the Hc fragment in this study. The analogue differs from the native GT1-b in that Sia6 is the β-anomer and the ceramide group has been replaced.<ref name="hcfrag" />]] | ||
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The Hc fragment has two binding sites in the β-trefoil domain:<ref name="hcfrag" /> | The Hc fragment has two binding sites in the β-trefoil domain:<ref name="hcfrag" /> | ||
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</StructureSection> | |||
==3D structures of tetanus toxin== | ==3D structures of tetanus toxin== | ||
