4dvt: Difference between revisions

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<StructureSection load='4dvt' size='340' side='right' caption='[[4dvt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4dvt' size='340' side='right' caption='[[4dvt]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dvt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dvt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DVT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LZ:N-(4-CHLORO-3-FLUOROPHENYL)-N-[(1S)-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YLMETHYL]ETHANEDIAMIDE'>0LZ</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0LZ:N-(4-CHLORO-3-FLUOROPHENYL)-N-[(1S)-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YLMETHYL]ETHANEDIAMIDE'>0LZ</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dvr|4dvr]], [[4dvs|4dvs]], [[4dvu|4dvu]], [[4dvv|4dvv]], [[4dvw|4dvw]], [[4dvx|4dvx]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dvr|4dvr]], [[4dvs|4dvs]], [[4dvu|4dvu]], [[4dvv|4dvv]], [[4dvw|4dvw]], [[4dvx|4dvx]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">env, HIV-1 Env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvt OCA], [http://pdbe.org/4dvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dvt RCSB], [http://www.ebi.ac.uk/pdbsum/4dvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvt OCA], [http://pdbe.org/4dvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dvt RCSB], [http://www.ebi.ac.uk/pdbsum/4dvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kwon,Y D]]
[[Category: Kwon, Y D]]
[[Category: Kwong, P D]]
[[Category: Kwong, P D]]
[[Category: As-ii-37]]
[[Category: As-ii-37]]

Revision as of 09:18, 3 August 2017

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37

4dvt, resolution 2.40Å

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