3rc4: Difference between revisions

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<StructureSection load='3rc4' size='340' side='right' caption='[[3rc4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3rc4' size='340' side='right' caption='[[3rc4]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rc4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RC4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rc4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RC4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rc6|3rc6]], [[3rc5|3rc5]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rc6|3rc6]], [[3rc5|3rc5]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31646 Hepatitis C virus subtype 1a])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rc4 OCA], [http://pdbe.org/3rc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rc4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rc4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rc4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rc4 OCA], [http://pdbe.org/3rc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rc4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rc4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rc4 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TCAM1_HUMAN TCAM1_HUMAN]] Herpetic encephalitis. Herpes simplex encephalitis 4 (HSE4) [MIM:[http://omim.org/entry/614850 614850]]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:22105173</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/TCAM1_HUMAN TCAM1_HUMAN]] Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.<ref>PMID:12471095</ref> <ref>PMID:12539043</ref> <ref>PMID:14739303</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Romano, K P]]
[[Category: Romano, K P]]
[[Category: Schiffer, C A]]
[[Category: Schiffer, C A]]

Revision as of 09:25, 3 August 2017

Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease

3rc4, resolution 1.50Å

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