5ulp: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ulp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ulp OCA], [http://pdbe.org/5ulp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ulp RCSB], [http://www.ebi.ac.uk/pdbsum/5ulp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ulp ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 A) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2'OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses.

Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.,Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK Sci Rep. 2017 May 9;7(1):1632. doi: 10.1038/s41598-017-01756-7. PMID:28487506<ref>PMID:28487506</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

__TOC__

</StructureSection>

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@@ Line 8: / Line 8: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ulp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ulp OCA], [http://pdbe.org/5ulp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ulp RCSB], [http://www.ebi.ac.uk/pdbsum/5ulp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ulp ProSAT]</span></td></tr>
 </table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 A) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2'OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses.
+Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.,Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK Sci Rep. 2017 May 9;7(1):1632. doi: 10.1038/s41598-017-01756-7. PMID:28487506<ref>PMID:28487506</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 5ulp" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
 __TOC__
 </StructureSection>