1w8b: Difference between revisions
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|PDB= 1w8b |SIZE=350|CAPTION= <scene name='initialview01'>1w8b</scene>, resolution 3.00Å | |PDB= 1w8b |SIZE=350|CAPTION= <scene name='initialview01'>1w8b</scene>, resolution 3.00Å | ||
|SITE= <scene name='pdbsite=AC1:413+Binding+Site+For+Chain+H'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:413+Binding+Site+For+Chain+H'>AC1</scene> | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=413:(S)-[(R)-2-(4-BENZYLOXY-3-METHOXY-PHENYL)-2-(4-CARBAMIMIDOYL-PHENYLAMINO)-ACETYLAMINO]-PHENYL-ACETIC+ACID'>413</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span> | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8b OCA], [http://www.ebi.ac.uk/pdbsum/1w8b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w8b RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. | We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Weber, L.]] | [[Category: Weber, L.]] | ||
[[Category: Wessel, H P.]] | [[Category: Wessel, H P.]] | ||
[[Category: coagulation]] | [[Category: coagulation]] | ||
[[Category: enzyme complex]] | [[Category: enzyme complex]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:32:35 2008'' | ||
