4p8h: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 4p8h is ON HOLD until Oct 28 2016~~

==Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a==

~~Authors: Neres, J., Cole, S.T.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4p8h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8H OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P8H FirstGlance].

~~Description:~~ Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O95:{(4S)-2-[7-(HYDROXYAMINO)-6-METHYL-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]-4,5-DIHYDRO-1,3-OXAZOL-4-YL}(PYRROLIDIN-1-YL)METHANONE'>O95</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

[[Category: Cole, S.T]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p8h OCA], [http://pdbe.org/4p8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p8h RCSB], [http://www.ebi.ac.uk/pdbsum/4p8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p8h ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Cole, S T]]

[[Category: Neres, J]]

[[Category: Complex]]

[[Category: Covalent]]

[[Category: Dpre1]]

[[Category: Inhibitor]]

[[Category: Nitro-benzothiazole 6a]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4p8h is ON HOLD  until Oct 28 2016
+==Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a==
+<StructureSection load='4p8h' size='340' side='right' caption='[[4p8h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Neres, J., Cole, S.T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4p8h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P8H FirstGlance]. <br>
-Description: Crystal structure of M. tuberculosis DprE1 in complex with the nitro-benzothiazole 6a
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O95:{(4S)-2-[7-(HYDROXYAMINO)-6-METHYL-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]-4,5-DIHYDRO-1,3-OXAZOL-4-YL}(PYRROLIDIN-1-YL)METHANONE'>O95</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p8c|4p8c]], [[4p8k|4p8k]], [[4p8l|4p8l]], [[4p8m|4p8m]], [[4p8n|4p8n]], [[4p8p|4p8p]], [[4p8t|4p8t]], [[4p8y|4p8y]]</td></tr>
-[[Category: Cole, S.T]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p8h OCA], [http://pdbe.org/4p8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p8h RCSB], [http://www.ebi.ac.uk/pdbsum/4p8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p8h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cole, S T]]
 [[Category: Neres, J]]
+[[Category: Complex]]
+[[Category: Covalent]]
+[[Category: Dpre1]]
+[[Category: Inhibitor]]
+[[Category: Nitro-benzothiazole 6a]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]