5mx9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mx9 is ~~ON HOLD~~

==High resolution crystal structure of the MCR-2 catalytic domain==

== Structural highlights ==

<table><tr><td colspan='2'>[[5mx9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX9 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx9 OCA], [http://pdbe.org/5mx9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mx9 RCSB], [http://www.ebi.ac.uk/pdbsum/5mx9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx9 ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 A resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an accurate starting model for further mechanistic studies.

~~Authors: Hinchliffe, P~~., Coates, K., Walsh, T.R., ~~Spencer, J~~.

1.12 A resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2.,Coates K, Walsh TR, Spencer J, Hinchliffe P Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):443-449. doi:, 10.1107/S2053230X17009669. Epub 2017 Jul 26. PMID:28777086<ref>PMID:28777086</ref>

~~Description: High resolution crystal structure~~ of the ~~MCR~~-~~2 catalytic domain~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Coates, K]]

[[Category: Hinchliffe, P]]

[[Category: Spencer, J]]

[[Category: Walsh, T.R]]

[[Category: Walsh, T R]]

[[Category: ~~Hinchliffe, P~~]]

[[Category: Antibiotic resistance]]

[[Category: ~~Coates, K~~]]

[[Category: Colistin]]

[[Category: Mcr-1]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mx9 is ON HOLD
+==High resolution crystal structure of the MCR-2 catalytic domain==
+<StructureSection load='5mx9' size='340' side='right' caption='[[5mx9]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mx9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX9 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx9 OCA], [http://pdbe.org/5mx9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mx9 RCSB], [http://www.ebi.ac.uk/pdbsum/5mx9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx9 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 A resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an accurate starting model for further mechanistic studies.
-Authors: Hinchliffe, P., Coates, K., Walsh, T.R., Spencer, J.
+.12 A resolution crystal structure of the catalytic domain of the plasmid-mediated colistin resistance determinant MCR-2.,Coates K, Walsh TR, Spencer J, Hinchliffe P Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):443-449. doi:, 10.1107/S2053230X17009669. Epub 2017 Jul 26. PMID:28777086<ref>PMID:28777086</ref>
-Description: High resolution crystal structure of the MCR-2 catalytic domain
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5mx9" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Coates, K]]
+[[Category: Hinchliffe, P]]
 [[Category: Spencer, J]]
-[[Category: Walsh, T.R]]
+[[Category: Walsh, T R]]
-[[Category: Hinchliffe, P]]
+[[Category: Antibiotic resistance]]
-[[Category: Coates, K]]
+[[Category: Colistin]]
+[[Category: Mcr-1]]
+[[Category: Transferase]]