5m2i: Difference between revisions
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==Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1== | |||
<StructureSection load='5m2i' size='340' side='right' caption='[[5m2i]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5m2i]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M2I FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m2i OCA], [http://pdbe.org/5m2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m2i RCSB], [http://www.ebi.ac.uk/pdbsum/5m2i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m2i ProSAT]</span></td></tr> | |||
[[ | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref> The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cambillau, C]] | [[Category: Cambillau, C]] | ||
[[Category: | [[Category: Desmyter, A]] | ||
[[Category: Haard, H de]] | |||
[[Category: Spinelli, S]] | [[Category: Spinelli, S]] | ||
[[Category: | [[Category: Cytokine]] | ||
Revision as of 14:39, 5 September 2017
Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1
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