5lrq: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5lrq is ~~ON HOLD~~

==BRD4 in complex with ERK5 inhibitor XMD8-92==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5lrq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRQ FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WG:2-{[2-ETHOXY-4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL]AMINO}-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4WG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lrq OCA], [http://pdbe.org/5lrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lrq RCSB], [http://www.ebi.ac.uk/pdbsum/5lrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lrq ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Martin, M P]]

[[Category: Noble, M E.M]]

[[Category: Brd4]]

[[Category: Bromodomain containing protein 4]]

[[Category: Erk5]]

[[Category: Inhibitor]]

[[Category: Transcription]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lrq is ON HOLD
+==BRD4 in complex with ERK5 inhibitor XMD8-92==
+<StructureSection load='5lrq' size='340' side='right' caption='[[5lrq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lrq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LRQ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WG:2-{[2-ETHOXY-4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL]AMINO}-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4WG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lrq OCA], [http://pdbe.org/5lrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lrq RCSB], [http://www.ebi.ac.uk/pdbsum/5lrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lrq ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Martin, M P]]
+[[Category: Noble, M E.M]]
+[[Category: Brd4]]
+[[Category: Bromodomain containing protein 4]]
+[[Category: Erk5]]
+[[Category: Inhibitor]]
+[[Category: Transcription]]