5xfc: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 5xfc is ON HOLD until Paper Publication~~

==Serial femtosecond X-ray structure of a stem domain of human O-mannose beta-1,2-N-acetylglucosaminyltransferase solved by Se-SAD using XFEL (refined against 13,000 patterns)==

~~Authors: Kuwabara, N., Fumiaki, Y., Kato, R., Manya, H.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5xfc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XFC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XFC FirstGlance].

~~Description:~~ Serial femtosecond X-ray structure of a stem domain of human O-mannose beta-1,2-N-acetylglucosaminyltransferase solved by Se-SAD using XFEL (refined against 13,000 patterns)

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MBE:4-NITROPHENYL-BETA-D-MANNOPYRANOSIDE'>MBE</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5xfd|5xfd]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xfc OCA], [http://pdbe.org/5xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xfc RCSB], [http://www.ebi.ac.uk/pdbsum/5xfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xfc ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/PMGT1_HUMAN PMGT1_HUMAN]] Walker-Warburg syndrome;Autosomal recessive limb-girdle muscular dystrophy type 2O;Congenital muscular dystrophy with cerebellar involvement;Muscle-eye-brain disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/PMGT1_HUMAN PMGT1_HUMAN]] Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.<ref>PMID:11709191</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Fumiaki, Y]]

[[Category: Kato, R]]

[[Category: Kuwabara, N]]

[[Category: Manya, H]]

[[Category: ~~Fumiaki, Y~~]]

[[Category: Carbohydrate-binding domain]]

[[Category: Glycosyltransferase]]

[[Category: Sugar binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5xfc is ON HOLD  until Paper Publication
+==Serial femtosecond X-ray structure of a stem domain of human O-mannose beta-1,2-N-acetylglucosaminyltransferase solved by Se-SAD using XFEL (refined against 13,000 patterns)==
+<StructureSection load='5xfc' size='340' side='right' caption='[[5xfc]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors: Kuwabara, N., Fumiaki, Y., Kato, R., Manya, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5xfc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XFC FirstGlance]. <br>
-Description: Serial femtosecond X-ray structure of a stem domain of human O-mannose beta-1,2-N-acetylglucosaminyltransferase solved by Se-SAD using XFEL (refined against 13,000 patterns)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MBE:4-NITROPHENYL-BETA-D-MANNOPYRANOSIDE'>MBE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xfd|5xfd]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xfc OCA], [http://pdbe.org/5xfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xfc RCSB], [http://www.ebi.ac.uk/pdbsum/5xfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xfc ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PMGT1_HUMAN PMGT1_HUMAN]] Walker-Warburg syndrome;Autosomal recessive limb-girdle muscular dystrophy type 2O;Congenital muscular dystrophy with cerebellar involvement;Muscle-eye-brain disease. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/PMGT1_HUMAN PMGT1_HUMAN]] Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.<ref>PMID:11709191</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fumiaki, Y]]
 [[Category: Kato, R]]
 [[Category: Kuwabara, N]]
 [[Category: Manya, H]]
-[[Category: Fumiaki, Y]]
+[[Category: Carbohydrate-binding domain]]
+[[Category: Glycosyltransferase]]
+[[Category: Sugar binding protein]]