5vkp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vkp is ~~ON HOLD~~ ~~until Paper Publication~~

==K2P2.1(TREK-1):ML402 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vkp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKP FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=16C:N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE'>16C</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=Q5F:N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide'>Q5F</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5vk5|5vk5]], [[5vkn|5vkn]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkp OCA], [http://pdbe.org/5vkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vkp RCSB], [http://www.ebi.ac.uk/pdbsum/5vkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkp ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KCNK2_MOUSE KCNK2_MOUSE]] Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).<ref>PMID:10321245</ref> <ref>PMID:16636285</ref> <ref>PMID:24496152</ref> <ref>PMID:9003761</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Lolicato, M]]

[[Category: Minor, D L]]

[[Category: Transport protein]]

[[Category: Trek-1 ion channel k2p ml402 small molecule binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vkp is ON HOLD  until Paper Publication
+==K2P2.1(TREK-1):ML402 complex==
+<StructureSection load='5vkp' size='340' side='right' caption='[[5vkp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vkp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKP FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16C:N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE'>16C</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=Q5F:N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide'>Q5F</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vk5|5vk5]], [[5vkn|5vkn]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkp OCA], [http://pdbe.org/5vkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vkp RCSB], [http://www.ebi.ac.uk/pdbsum/5vkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KCNK2_MOUSE KCNK2_MOUSE]] Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).<ref>PMID:10321245</ref> <ref>PMID:16636285</ref> <ref>PMID:24496152</ref> <ref>PMID:9003761</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lolicato, M]]
+[[Category: Minor, D L]]
+[[Category: Transport protein]]
+[[Category: Trek-1 ion channel k2p ml402 small molecule binding]]