Saposin: Difference between revisions
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<StructureSection load='2dob' size='350' side='right' scene='' caption='Human saposin A complex with Ca+2 [[2dob]]'> | |||
== Function == | == Function == | ||
'''Saposin''' (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains (cleaved to saposin A,B,C and D) and 2 SapA domains which are cleaved off<ref>PMID:2001789</ref>. | '''Saposin''' (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains (cleaved to saposin A,B,C and D) and 2 SapA domains which are cleaved off<ref>PMID:2001789</ref>. | ||
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== Disease == | == Disease == | ||
Mutations in saposin B are autosomal recessive trait resulting in clinical metachromatic leukodystrophy<ref>PMID:17616409</ref>. Mutations in saposin D cause urinary system defects<ref>PMID:15345707</ref>. | Mutations in saposin B are autosomal recessive trait resulting in clinical metachromatic leukodystrophy<ref>PMID:17616409</ref>. Mutations in saposin D cause urinary system defects<ref>PMID:15345707</ref>. | ||
</StructureSection> | |||
== 3D Structures of Saposin == | == 3D Structures of Saposin == | ||
