5woa: Difference between revisions
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The | ==Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Gadolinium== | ||
<StructureSection load='5woa' size='340' side='right' caption='[[5woa]], [[Resolution|resolution]] 3.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5woa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WOA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5woa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5woa OCA], [http://pdbe.org/5woa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5woa RCSB], [http://www.ebi.ac.uk/pdbsum/5woa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5woa ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states. | |||
Swapping of transmembrane domains in the epithelial calcium channel TRPV6.,Singh AK, Saotome K, Sobolevsky AI Sci Rep. 2017 Sep 6;7(1):10669. doi: 10.1038/s41598-017-10993-9. PMID:28878326<ref>PMID:28878326</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5woa" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Saotome, K]] | [[Category: Saotome, K]] | ||
[[Category: Singh, A | [[Category: Singh, A K]] | ||
[[Category: Sobolevsky, A I]] | |||
[[Category: Ion channel]] | |||
[[Category: Membrane protein]] | |||
[[Category: Transporter]] | |||
Revision as of 09:25, 4 October 2017
Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Gadolinium
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