1ya3: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= NR3C2, MCR, MLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= NR3C2, MCR, MLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ya3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ya3 OCA], [http://www.ebi.ac.uk/pdbsum/1ya3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ya3 RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L. | The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Rafestin-Oblin, M E.]] | [[Category: Rafestin-Oblin, M E.]] | ||
[[Category: Rochel, M.]] | [[Category: Rochel, M.]] | ||
[[Category: activating mutation]] | [[Category: activating mutation]] | ||
[[Category: hypertension]] | [[Category: hypertension]] | ||
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[[Category: steroid receptor]] | [[Category: steroid receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:00:43 2008'' | ||
