5jjd: Difference between revisions

Revision as of 07:24, 6 October 2017

crystal structure of the ceramide transfer protein PH and START domain complex

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[1] Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature. 2003 Dec 18;426(6968):803-9. PMID:14685229 doi:https://dx.doi.org/10.1038/nature02188

[2] Fugmann T, Hausser A, Schoffler P, Schmid S, Pfizenmaier K, Olayioye MA. Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. J Cell Biol. 2007 Jul 2;178(1):15-22. Epub 2007 Jun 25. PMID:17591919 doi:https://dx.doi.org/jcb.200612017

[3] Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M, Hanada K, Kato R. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):488-93. Epub 2008 Jan 9. PMID:18184806

[4] Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, Kato R. Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. J Mol Biol. 2010 Feb 19;396(2):245-51. Epub 2009 Dec 28. PMID:20036255 doi:10.1016/j.jmb.2009.12.029

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-'''Unreleased structure'''
-The entry 5jjd is ON HOLD  until Jul 26 2018
+==crystal structure of the ceramide transfer protein PH and START domain complex==
+<StructureSection load='5jjd' size='340' side='right' caption='[[5jjd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5jjd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JJD FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jjd OCA], [http://pdbe.org/5jjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jjd RCSB], [http://www.ebi.ac.uk/pdbsum/5jjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jjd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/C43BP_HUMAN C43BP_HUMAN]] Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.<ref>PMID:14685229</ref> <ref>PMID:17591919</ref> <ref>PMID:18184806</ref> <ref>PMID:20036255</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bouyain, S]]
+[[Category: Prashek, J]]
+[[Category: Yao, X]]
+[[Category: Cert]]
+[[Category: Complex]]
+[[Category: Lipid transport]]
+[[Category: Ph]]
+[[Category: Start]]

5jjd: Difference between revisions

Revision as of 07:24, 6 October 2017

crystal structure of the ceramide transfer protein PH and START domain complex

Structural highlights

Function

References

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