Telethonin: Difference between revisions
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<StructureSection load='1ya5' size='450' side='right' scene='Telethonin/Cv/1' caption='Crystal structure of telethonin (dark green) in complex with titin domains z1z2 dimer (grey and light green) and sulfate (PDB code [[1ya5]])'> | |||
== Function == | == Function == | ||
[[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly<ref>PMID:11699871</ref>. It is called [[titin]] cap protein. See also [[Group:MUZIC:Telethonin]]. | [[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly<ref>PMID:11699871</ref>. It is called [[titin]] cap protein. See also [[Group:MUZIC:Telethonin]]. | ||
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== Disease == | == Disease == | ||
Mutations in telethonin lead to heart maladptation to biomechanical stress<ref>PMID:21799151</ref>. | Mutations in telethonin lead to heart maladptation to biomechanical stress<ref>PMID:21799151</ref>. | ||
</StructureSection> | |||
== 3D Structures of Telethonin == | == 3D Structures of Telethonin == | ||
