5gph: Difference between revisions
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==Solution structure of the Pin1-PPIase (S138A) mutant== | |||
<StructureSection load='5gph' size='340' side='right' caption='[[5gph]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gph]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GPH FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gph OCA], [http://pdbe.org/5gph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gph RCSB], [http://www.ebi.ac.uk/pdbsum/5gph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gph ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Peptidylprolyl isomerase]] | |||
[[Category: Tate, S]] | |||
[[Category: Tochio, N]] | |||
[[Category: Wang, J]] | |||
[[Category: Isomerase]] | |||
[[Category: Molmol]] | |||
[[Category: Pin1]] | |||
[[Category: Ppiase]] | |||
[[Category: S138a]] | |||
Revision as of 10:22, 7 October 2017
Solution structure of the Pin1-PPIase (S138A) mutant
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