5l1n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5l1n is ~~ON HOLD until Paper Publication~~

==Pyrococcus horikoshii CoA Disulfide Reductase Quadruple Mutant==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5l1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L1N OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L1N FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/CoA-disulfide_reductase CoA-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.14 1.8.1.14] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l1n OCA], [http://pdbe.org/5l1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l1n RCSB], [http://www.ebi.ac.uk/pdbsum/5l1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l1n ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CDR_PYRHO CDR_PYRHO]] Acts as a coenzyme A disulfide reductase. Specific for CoA disulfide. Shows a slow NAD(P)H oxidase activity in the presence of high concentrations of substrate-level FAD. This demonstrates that it is not likely to act as an NADH oxidase in vivo.

__TOC__

</StructureSection>

[[Category: CoA-disulfide reductase]]

[[Category: Chen, B]]

[[Category: III, E J.Crane]]

[[Category: Sazinsky, M H]]

[[Category: Sea, K]]

[[Category: Oxidoreductase]]

[[Category: Sulfur metabolism half-sites reactivity]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5l1n is ON HOLD  until Paper Publication
+==Pyrococcus horikoshii CoA Disulfide Reductase Quadruple Mutant==
+<StructureSection load='5l1n' size='340' side='right' caption='[[5l1n]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5l1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L1N FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CoA-disulfide_reductase CoA-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.14 1.8.1.14] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l1n OCA], [http://pdbe.org/5l1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l1n RCSB], [http://www.ebi.ac.uk/pdbsum/5l1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l1n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CDR_PYRHO CDR_PYRHO]] Acts as a coenzyme A disulfide reductase. Specific for CoA disulfide. Shows a slow NAD(P)H oxidase activity in the presence of high concentrations of substrate-level FAD. This demonstrates that it is not likely to act as an NADH oxidase in vivo.
+__TOC__
+</StructureSection>
+[[Category: CoA-disulfide reductase]]
+[[Category: Chen, B]]
+[[Category: III, E J.Crane]]
+[[Category: Sazinsky, M H]]
+[[Category: Sea, K]]
+[[Category: Oxidoreductase]]
+[[Category: Sulfur metabolism half-sites reactivity]]