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| <StructureSection load='' size='450' side='right' caption='Dipeptide:H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Cv/1'> | | <StructureSection load='' size='450' side='right' caption='Dipeptide:H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/1'> |
| == Function == | | == Function == |
| Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. | | Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>. |
Revision as of 13:20, 9 October 2017
| Function
Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction[1].
Disease
Mutations in sodium/iodide symporter cause iodide transport defects[2].
Structural highlights
Dipeptide:H symporter binds the dipeptide between its N- and C-terminal bundles[3].
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:https://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:https://dx.doi.org/10.15252/embr.201338403
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3D Structures of symporter
Updated on 09-October-2017
{"openlevels":0}
- D-xylose/H+ symporter
- 4ja4, 4qiq – EcSymp – Escherichia coli
- 4ja3 – EcSymp (mutant)
- 4gby – EcSymp + xylose
- 4gbz, 4gc0 – EcSymp + glucose derivative
- Di-or tripeptide:H+ symporter
- Oligopeptide/H+ symporter
- Sodium/bile acid symporter
- 4n7w – YfSymp – Yersinia frederiksenii
- 4n7x – YfSymp (mutant)
- L-fucose/H+ symporter
- Sodium/glucose symporter
- 2xq2 – VpSymp (mutant) – Vibrio parahaemolyticus
- 3dh4 – VpSymp + galactose
- Sodium/citrate symporter
- 5a1s – Symp + citrate – Salmonella enterica
- 5x9r, 5xas, 5xat – KpSymp + citrate – Klebsiella pneumoniae
- 5xar – KpSymp
- Divalent ion/sodium symporter
- Purine/H+ symporter
- 5i6c – Symp + xanthine – Aspergillus nidulans
- Glutamate/H+ symporter
- 5dwy – TkSymp – Thermococcus kodakarensis
- 5e9s – TkSymp + aspartate
References
