1yho: Difference between revisions

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|PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene>
|PDB= 1yho |SIZE=350|CAPTION= <scene name='initialview01'>1yho</scene>
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene>
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span>
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=[[1kms|1KMS]], [[1kmv|1KMV]], [[1lud|1LUD]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yho OCA], [http://www.ebi.ac.uk/pdbsum/1yho PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yho RCSB]</span>
}}
}}


'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''
'''Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures'''


==Disease==
Known disease associated with this structure: Anemia, megaloblastic, due to DHFR deficiency (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126060 126060]]


==About this Structure==
==About this Structure==
Line 25: Line 25:
[[Category: Birdsall, B.]]
[[Category: Birdsall, B.]]
[[Category: Polshakov, V I.]]
[[Category: Polshakov, V I.]]
[[Category: NDP]]
[[Category: TRR]]
[[Category: dhfr]]
[[Category: dhfr]]
[[Category: inhibitor/enzyme complex]]
[[Category: inhibitor/enzyme complex]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:07:36 2008''
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