5w9s: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5w9s ~~is ON HOLD until Jun 23 2019~~

==Zinc finger of human CXXC5 in complex with CpG DNA==

~~Authors~~: ~~Liu, K~~., Xu, C., ~~Tempel~~, W., ~~Walker~~, J.R., ~~Bountra, C~~.~~, Arrowsmith, C~~.H., ~~Edwards, A~~.M., ~~Min, J~~.~~, Structural Genomics Consortium~~ (~~SGC~~)

== Structural highlights ==

<table><tr><td colspan='2'>[[5w9s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W9S FirstGlance]. <br>

~~Description~~: ~~Zinc finger of human CXXC5 in complex with CpG DNA~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w9s OCA], [http://pdbe.org/5w9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w9s RCSB], [http://www.ebi.ac.uk/pdbsum/5w9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w9s ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CXXC5_HUMAN CXXC5_HUMAN]] May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).<ref>PMID:19182210</ref> <ref>PMID:19557330</ref> <ref>PMID:23303788</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Liu, K]]

[[Category: Min, J]]

[[Category: ~~Walker, J.R]]~~

[[Category: Structural genomic]]

~~[[Category: Bountra, C~~]]

[[Category: Tempel, W]]

[[Category: ~~Arrowsmith~~, ~~C.H~~]]

[[Category: Walker, J R]]

[[Category: Xu, C]]

[[Category: ~~Liu, K~~]]

[[Category: Dna binding protein-dna complex]]

[[Category: ~~Edwards, A.M]]~~

[[Category: Sgc]]

~~[[Category: Structural Genomics Consortium (~~Sgc)]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5w9s is ON HOLD  until Jun 23 2019
+==Zinc finger of human CXXC5 in complex with CpG DNA==
+<StructureSection load='5w9s' size='340' side='right' caption='[[5w9s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Liu, K., Xu, C., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5w9s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W9S FirstGlance]. <br>
-Description: Zinc finger of human CXXC5 in complex with CpG DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w9s OCA], [http://pdbe.org/5w9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w9s RCSB], [http://www.ebi.ac.uk/pdbsum/5w9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w9s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CXXC5_HUMAN CXXC5_HUMAN]] May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).<ref>PMID:19182210</ref> <ref>PMID:19557330</ref> <ref>PMID:23303788</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C H]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
+[[Category: Liu, K]]
 [[Category: Min, J]]
-[[Category: Walker, J.R]]
+[[Category: Structural genomic]]
-[[Category: Bountra, C]]
 [[Category: Tempel, W]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Walker, J R]]
 [[Category: Xu, C]]
-[[Category: Liu, K]]
+[[Category: Dna binding protein-dna complex]]
-[[Category: Edwards, A.M]]
+[[Category: Sgc]]
-[[Category: Structural Genomics Consortium (Sgc)]]