CD47

spinqualitylabelsall models Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRPα (cyan) and I- ions 2jjs Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD47 (Cluster of Differentiation 47) is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. Relevance Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested. CD47 is an antigen on a variety of human cancer cells. Structural insights CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. CD47 with SIRP α (cyan) and I-ions (2jjs).

3D Structures of CD47

Updated on 19-October-2017

2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate
5iwl – hCD47 extracellular domain (mutant) + 5F9 diabody

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Michal Harel, Alexander Berchansky, Joel L. Sussman