Factor IX: Difference between revisions

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<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> ('''plasma thromboplastin component''', '''Christmas factor''', or '''hemophilia B factor''') is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.

Factor IX: Difference between revisions

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Revision as of 09:12, 11 May 2017 view source Michal Harel (talk \| contribs) 32,820 edits No edit summary ← Older edit		Revision as of 18:49, 19 October 2017 view source Michal Harel (talk \| contribs) 32,820 edits No edit summary Newer edit →
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	<StructureSection load='3lc3' size='350' side='right' scene='' caption='Human factor IX residues 133-188 (green~~, yellow~~), residues 227-461 (grey~~, pink~~) complex with benzothiophene inhibitor and Ca+2 ions (green) (PDB code [[3lc3]])'>		<StructureSection load='3lc3' size='350' side='right' scene='' caption='Human factor IX residues 133-188 (green), residues 227-461 (grey) complex with benzothiophene inhibitor and Ca+2 ions (green) (PDB code [[3lc3]])'>

	<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> ('''plasma thromboplastin component''', '''Christmas factor''', or '''hemophilia B factor''') is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.		<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> ('''plasma thromboplastin component''', '''Christmas factor''', or '''hemophilia B factor''') is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.