Interferon: Difference between revisions
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The low-affinity receptor chain, IFNAR1, also <scene name='User:David_Canner/Workbench3/Morph_4/4'>undergoes major conformational changes</scene> upon ligand binding. When using D1 as anchor, D3 is moving inwards (toward the ligand) by ~15 Å. This would generate an even larger movement of the membrane-proximal SD4 domain and the transmembrane helix. The conformational changes in IFNAR1 are necessary to form the full spectrum of interactions with the IFN ligand, and to form a stable signaling complex that is able to instigate downstream signaling. In contrast to SD3, SD4 seems to be highly flexible (even more than D2 of IFNAR2). One might suggest that the conformational changes in IFNAR1 by itself will be responsible for a reduced binding affinity of IFNAR1 and may slow down the rate of ligand association to IFNAR1 directly from solution. | The low-affinity receptor chain, IFNAR1, also <scene name='User:David_Canner/Workbench3/Morph_4/4'>undergoes major conformational changes</scene> upon ligand binding. When using D1 as anchor, D3 is moving inwards (toward the ligand) by ~15 Å. This would generate an even larger movement of the membrane-proximal SD4 domain and the transmembrane helix. The conformational changes in IFNAR1 are necessary to form the full spectrum of interactions with the IFN ligand, and to form a stable signaling complex that is able to instigate downstream signaling. In contrast to SD3, SD4 seems to be highly flexible (even more than D2 of IFNAR2). One might suggest that the conformational changes in IFNAR1 by itself will be responsible for a reduced binding affinity of IFNAR1 and may slow down the rate of ligand association to IFNAR1 directly from solution. | ||
==See Also== | |||
*[[Interferon receptor|Interferon receptor]] | |||
*[[Multiple sclerosis|Multiple sclerosis]] | |||
*[[Journal:Cell:1|Structural linkage between ligand discrimination and receptor activation by type I interferons]] | |||
__NOTOC__ | __NOTOC__ | ||
</StructureSection> | </StructureSection> | ||
