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| <StructureSection load='2xcb' size='350' side='right' caption='PcrH (magenta, green) complex with PopD chaperone binding peptide (cyan) and NO3- ion (PDB code [[2xcb]])' scene='72/725368/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='PcrH (magenta, green) complex with PopD chaperone binding peptide (cyan) and NO3- ion (PDB code [[2xcb]])' scene='72/725368/Cv/1'> |
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| == Function == | | == Function == |
Revision as of 06:23, 21 October 2017
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Function
PcrH or Regulatory protein PcrH is a chaperone protein which is a member of the translocon system which enables bacteria to form a pore in the cell wall for the insertion of toxins into it[1]. See details in Molecular Playground/Pcr H.
Structural highlights
PcrH contains a helical Tpr domain (tetratricopeptide) which interacts with the translocator PopD or PopB peptide. PopD peptide binds at the concave surface of PcrH. NO3- ion binding site (PDB code 2xcb). [2]
- ↑ Broms JE, Forslund AL, Forsberg A, Francis MS. PcrH of Pseudomonas aeruginosa is essential for secretion and assembly of the type III translocon. J Infect Dis. 2003 Dec 15;188(12):1909-21. Epub 2003 Dec 3. PMID:14673772 doi:https://dx.doi.org/10.1086/379898
- ↑ Job V, Mattei PJ, Lemaire D, Attree I, Dessen A. Structural basis of chaperone recognition of type III secretion system minor translocator proteins. J Biol Chem. 2010 Jul 23;285(30):23224-32. Epub 2010 Apr 12. PMID:20385547 doi:10.1074/jbc.M110.111278
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3D Structures of PcrH
Updated on 21-October-2017
Molecular Playground/Pcr H - PaPcrH – Pseudomonas aeruginosa
2xcb - PaPcrH + PopD chaperone-binding peptide
4jl0 - PaPcrH + PopB chaperone-binding peptide
References
