6awo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6awo is ~~ON HOLD until Paper Publication~~

==X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site==

~~Authors~~: ~~Coleman~~, J.A., ~~Gouaux~~, E.

== Structural highlights ==

<table><tr><td colspan='2'>[[6awo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AWO FirstGlance]. <br>

~~Description~~: X-~~ray structure~~ of the ~~ts3 human~~ serotonin ~~transporter complexed with sertraline at~~ the ~~central site~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRE:(1S,4S)-4-(3,4-DICHLOROPHENYL)-N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE'>SRE</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6awo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awo OCA], [http://pdbe.org/6awo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6awo RCSB], [http://www.ebi.ac.uk/pdbsum/6awo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6awo ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Coleman, J A]]

[[Category: Gouaux, E]]

[[Category: ~~Coleman, J.A~~]]

[[Category: Antidepressant]]

[[Category: Neurotransmitter transporter]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6awo is ON HOLD  until Paper Publication
+==X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site==
+<StructureSection load='6awo' size='340' side='right' caption='[[6awo]], [[Resolution|resolution]] 3.53&Aring;' scene=''>
-Authors: Coleman, J.A., Gouaux, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6awo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AWO FirstGlance]. <br>
-Description: X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRE:(1S,4S)-4-(3,4-DICHLOROPHENYL)-N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE'>SRE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6awo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awo OCA], [http://pdbe.org/6awo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6awo RCSB], [http://www.ebi.ac.uk/pdbsum/6awo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6awo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Coleman, J A]]
 [[Category: Gouaux, E]]
-[[Category: Coleman, J.A]]
+[[Category: Antidepressant]]
+[[Category: Neurotransmitter transporter]]
+[[Category: Transport protein]]