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'''Unreleased structure'''


The entry 6eim is ON HOLD
==Human STK10 bound to GW683134A==
 
<StructureSection load='6eim' size='340' side='right' caption='[[6eim]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
Authors: Sorrell, F.J., Berger, B.-T., Salah, E., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6eim]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EIM FirstGlance]. <br>
Description: Human STK10 bound to GW683134A
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B6E:~{N}-[5-[4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1~{H}-benzimidazol-2-yl]furan-2-carboxamide'>B6E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5owr|5owr]], [[5owq|5owq]]</td></tr>
[[Category: Elkins, J.M]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
[[Category: Berger, B.-T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eim OCA], [http://pdbe.org/6eim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eim RCSB], [http://www.ebi.ac.uk/pdbsum/6eim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eim ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C]]
[[Category: Berger, B T]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Elkins, J M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
[[Category: Bountra, C]]
[[Category: Sorrell, F.J]]
[[Category: Von Delft, F]]
[[Category: Arrowsmith, C]]
[[Category: Edwards, A.M]]
[[Category: Salah, E]]
[[Category: Salah, E]]
[[Category: Sorrell, F J]]
[[Category: Complex]]
[[Category: Inhibitor]]
[[Category: Kinase]]
[[Category: Lok]]
[[Category: Transferase]]
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