3iec

Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

spinqualitylabelsall models 3iec, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3iec is a 8 chain structure with sequence from Atcc 43504 and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: CagA, EMK1, MARK2 (HUMAN), cagA, cai (ATCC 43504) Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CAGA_HELPY] May be necessary for the transcription, folding, export, or function of the cytotoxin. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase family, resembling eukaryotic protein kinase inhibitors. Mutagenesis of conserved residues central to this interaction renders CagA inactive as an inhibitor of MARK2. Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.,Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE Nat Struct Mol Biol. 2010 Jan;17(1):130-2. Epub 2009 Dec 6. PMID:19966800 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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