Sandbox k11v: Difference between revisions
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Oligomer forming segment of ABC were identified by inspection of its 3D structure and by applying the Rosetta-Profile algorithm to its sequence.Two segments of high amyloidogenic propensity,with sequences KVKVLG and GDVIEV (where D indicates Asp; E, Glu; G, Gly; I, Ile; K, Lys; and V, Val). | Oligomer forming segment of ABC were identified by inspection of its 3D structure and by applying the Rosetta-Profile algorithm to its sequence.Two segments of high amyloidogenic propensity,with sequences KVKVLG and GDVIEV (where D indicates Asp; E, Glu; G, Gly; I, Ile; K, Lys; and V, Val). | ||
The entire 11-residue segment KVKVLGDVIEV forms a <scene name='77/771966/K11v_in_black/1'>hairpin loop</scene> in the 3D structure of ABC. | The entire 11-residue segment KVKVLGDVIEV forms a <scene name='77/771966/K11v_in_black/1'>hairpin loop</scene> in the 3D structure of ABC.The six residue segment GDVIEV ,termed <scene name='77/771966/Gdviev_black/1'>G6V</scene>,forms fibrils and microcrystals.THe microcrystals enabled us to determine the atomic structure of G6V, which proved to be a standard class 2 steric zipper, essentially an amyloid-like protofilament. | ||
[[Image:Table_abc_first_ok.jpg]] | |||
