5o1p: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
m Protected "5o1p" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 5o1p is ON HOLD
==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.==
 
<StructureSection load='5o1p' size='340' side='right' caption='[[5o1p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Kopec, J., Rembeza, E., Pena, I.A., Williams, E., Velupillai, S., Kupinska, K., Strain-Damerell, C., Goubin, S., Talon, R., Collins, P., Krojer, T., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., von Delft, F., Arruda, P., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5o1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O1P FirstGlance]. <br>
Description: Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AASS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
[[Category: Goubin, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o1p OCA], [http://pdbe.org/5o1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o1p RCSB], [http://www.ebi.ac.uk/pdbsum/5o1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o1p ProSAT]</span></td></tr>
[[Category: Collins, P]]
</table>
[[Category: Burgess-Brown, N]]
== Disease ==
[[Category: Williams, E]]
[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry.  The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref> 
[[Category: Velupillai, S]]
== Function ==
[[Category: Yue, W.W]]
[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
[[Category: Kopec, J]]
== References ==
[[Category: Von Delft, F]]
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith, C]]
[[Category: Talon, R]]
[[Category: Arruda, P]]
[[Category: Arruda, P]]
[[Category: Pena, I.A]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N]]
[[Category: Collins, P]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]
[[Category: Strain-Damerell, C]]
[[Category: Goubin, S]]
[[Category: Kopec, J]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Kupinska, K]]
[[Category: Pena, I A]]
[[Category: Rembeza, E]]
[[Category: Rembeza, E]]
[[Category: Bountra, C]]
[[Category: Strain-Damerell, C]]
[[Category: Kupinska, K]]
[[Category: Talon, R]]
[[Category: Velupillai, S]]
[[Category: Williams, E]]
[[Category: Yue, W W]]
[[Category: Human aminoadipate semialdehyde synthase]]
[[Category: Oxidoreductase]]
[[Category: Sdr]]
Retrieved from "https://proteopedia.org/5o1p"