6auj

Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1

spinqualitylabelsall models 6auj, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6auj is a 3 chain structure with sequence from Elizabethkingia anophelis nuhp1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PGE NonStd Res: M0H Gene: thyA, BD94_0762 (Elizabethkingia anophelis NUHP1) Activity: Thymidylate synthase, with EC number 2.1.1.45 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [A0A077EAN3_9FLAO] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]

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