5o0r: Difference between revisions

Revision as of 07:47, 8 November 2017

Deglycosylated Nogo Receptor with native disulfide structure

Structural highlights

5o0r is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	CL, GOL, NAG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RTN4R_MOUSE] Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (PubMed:22406547). Can also bind heparin (PubMed:22406547). Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615). Plays a role in postnatal brain development (PubMed:27339102). Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).[UniProtKB:Q9BZR6]^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8] ^[9]

References

↑ Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409(6818):341-6. PMID:11201742 doi:https://dx.doi.org/10.1038/35053072
↑ Liu BP, Fournier A, GrandPre T, Strittmatter SM. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002 Aug 16;297(5584):1190-3. Epub 2002 Jun 27. PMID:12089450 doi:https://dx.doi.org/10.1126/science.1073031
↑ Kim JE, Liu BP, Park JH, Strittmatter SM. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28;44(3):439-51. PMID:15504325 doi:https://dx.doi.org/10.1016/j.neuron.2004.10.015
↑ Mathis C, Schroter A, Thallmair M, Schwab ME. Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010 Oct;20(10):2380-90. doi: 10.1093/cercor/bhp307. Epub 2010 Jan , 21. PMID:20093372 doi:https://dx.doi.org/10.1093/cercor/bhp307
↑ Wills ZP, Mandel-Brehm C, Mardinly AR, McCord AE, Giger RJ, Greenberg ME. The nogo receptor family restricts synapse number in the developing hippocampus. Neuron. 2012 Feb 9;73(3):466-81. doi: 10.1016/j.neuron.2011.11.029. PMID:22325200 doi:https://dx.doi.org/10.1016/j.neuron.2011.11.029
↑ Dickendesher TL, Baldwin KT, Mironova YA, Koriyama Y, Raiker SJ, Askew KL, Wood A, Geoffroy CG, Zheng B, Liepmann CD, Katagiri Y, Benowitz LI, Geller HM, Giger RJ. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012 Mar 11;15(5):703-12. doi: 10.1038/nn.3070. PMID:22406547 doi:https://dx.doi.org/10.1038/nn.3070
↑ Nakaya N, Sultana A, Lee HS, Tomarev SI. Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J Biol Chem. 2012 Oct 26;287(44):37171-84. doi: 10.1074/jbc.M112.389916. Epub, 2012 Aug 24. PMID:22923615 doi:https://dx.doi.org/10.1074/jbc.M112.389916
↑ Palandri A, Salvador VR, Wojnacki J, Vivinetto AL, Schnaar RL, Lopez PH. Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis. 2015 Sep 3;6:e1876. doi: 10.1038/cddis.2015.228. PMID:26335717 doi:https://dx.doi.org/10.1038/cddis.2015.228
↑ Yoo SW, Motari MG, Schnaar RL. Agenesis of the corpus callosum in Nogo receptor deficient mice. J Comp Neurol. 2017 Feb 1;525(2):291-301. doi: 10.1002/cne.24064. Epub 2016 Jul, 8. PMID:27339102 doi:https://dx.doi.org/10.1002/cne.24064

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409(6818):341-6. PMID:11201742 doi:https://dx.doi.org/10.1038/35053072

[2] Liu BP, Fournier A, GrandPre T, Strittmatter SM. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002 Aug 16;297(5584):1190-3. Epub 2002 Jun 27. PMID:12089450 doi:https://dx.doi.org/10.1126/science.1073031

[3] Kim JE, Liu BP, Park JH, Strittmatter SM. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28;44(3):439-51. PMID:15504325 doi:https://dx.doi.org/10.1016/j.neuron.2004.10.015

[4] Mathis C, Schroter A, Thallmair M, Schwab ME. Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010 Oct;20(10):2380-90. doi: 10.1093/cercor/bhp307. Epub 2010 Jan , 21. PMID:20093372 doi:https://dx.doi.org/10.1093/cercor/bhp307

[5] Wills ZP, Mandel-Brehm C, Mardinly AR, McCord AE, Giger RJ, Greenberg ME. The nogo receptor family restricts synapse number in the developing hippocampus. Neuron. 2012 Feb 9;73(3):466-81. doi: 10.1016/j.neuron.2011.11.029. PMID:22325200 doi:https://dx.doi.org/10.1016/j.neuron.2011.11.029

[6] Dickendesher TL, Baldwin KT, Mironova YA, Koriyama Y, Raiker SJ, Askew KL, Wood A, Geoffroy CG, Zheng B, Liepmann CD, Katagiri Y, Benowitz LI, Geller HM, Giger RJ. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012 Mar 11;15(5):703-12. doi: 10.1038/nn.3070. PMID:22406547 doi:https://dx.doi.org/10.1038/nn.3070

[7] Nakaya N, Sultana A, Lee HS, Tomarev SI. Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J Biol Chem. 2012 Oct 26;287(44):37171-84. doi: 10.1074/jbc.M112.389916. Epub, 2012 Aug 24. PMID:22923615 doi:https://dx.doi.org/10.1074/jbc.M112.389916

[8] Palandri A, Salvador VR, Wojnacki J, Vivinetto AL, Schnaar RL, Lopez PH. Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways. Cell Death Dis. 2015 Sep 3;6:e1876. doi: 10.1038/cddis.2015.228. PMID:26335717 doi:https://dx.doi.org/10.1038/cddis.2015.228

[9] Yoo SW, Motari MG, Schnaar RL. Agenesis of the corpus callosum in Nogo receptor deficient mice. J Comp Neurol. 2017 Feb 1;525(2):291-301. doi: 10.1002/cne.24064. Epub 2016 Jul, 8. PMID:27339102 doi:https://dx.doi.org/10.1002/cne.24064

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5o0r is ON HOLD
+==Deglycosylated Nogo Receptor with native disulfide structure==
+<StructureSection load='5o0r' size='340' side='right' caption='[[5o0r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5o0r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O0R FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o0r OCA], [http://pdbe.org/5o0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o0r RCSB], [http://www.ebi.ac.uk/pdbsum/5o0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o0r ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RTN4R_MOUSE RTN4R_MOUSE]] Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (PubMed:22406547). Can also bind heparin (PubMed:22406547). Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615). Plays a role in postnatal brain development (PubMed:27339102). Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).[UniProtKB:Q9BZR6]<ref>PMID:11201742</ref> <ref>PMID:12089450</ref> <ref>PMID:15504325</ref> <ref>PMID:20093372</ref> <ref>PMID:22325200</ref> <ref>PMID:22406547</ref> <ref>PMID:22923615</ref> <ref>PMID:26335717</ref> <ref>PMID:27339102</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Janssen, B J.C]]
+[[Category: Pronker, M F]]
+[[Category: Disulfide structure]]
+[[Category: Leucine-rich repeat domain]]
+[[Category: Nervous system]]
+[[Category: Signaling]]
+[[Category: Signaling protein]]

5o0r: Difference between revisions

Revision as of 07:47, 8 November 2017

Deglycosylated Nogo Receptor with native disulfide structure

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools