3n56: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 12: | Line 12: | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref> | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANFB_HUMAN ANFB_HUMAN]] Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:23, 8 November 2017
Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)
| ||||||||||||
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Human
- Insulysin
- Funke, T
- Guo, Q
- Tang, W J
- A-beta degrading enzyme
- Cardiac
- Cardiovascular regulation
- Cryptidase
- Diabetes mellitus
- Disease mutation
- Disulfide bond
- Hormone
- Human insulin-degradng enzyme
- Hydrolase
- Hydrolase-hormone complex
- Insulin
- Insulinase
- Metal-binding
- Metalloprotease
- Natriuretic factor
- Natriuretic peptide
- Protease
- Secreted
