3v8d

Crystal structure of human CYP7A1 in complex with 7-ketocholesterol

spinqualitylabelsall models 3v8d, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3v8d is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 0GV, HEM, SO4, UNX Gene: CYP7A1, CYP7 (HUMAN) Activity: Cholesterol 7-alpha-monooxygenase, with EC number 1.14.13.17 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.

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