Sandbox k11v: Difference between revisions
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== Molecular Tour == | == Molecular Tour == | ||
Oligomer forming segment of ABC were identified by inspection of its 3D structure and by applying the Rosetta-Profile algorithm to its sequence(Fig 1).Two segments of high amyloidogenic propensity,with sequences KVKVLG and GDVIEV (where D indicates Asp; E, Glu; G, Gly; I, Ile; K, Lys; and V, Val). | Oligomer forming segment of ABC were identified by inspection of its 3D structure and by applying the Rosetta-Profile algorithm to its sequence(Fig 1).Two segments of high amyloidogenic propensity,with sequences <scene name='77/771966/Only_kvkvlg/1'>KVKVLG</scene> and <scene name='77/771966/Only_gdviev/1'>GDVIEV</scene> (where D indicates Asp; E, Glu; G, Gly; I, Ile; K, Lys; and V, Val). | ||
[[Image:Rosetta_image.jpg | thumb | 300px | right | Fig. 1 : Ribbon diagram of a single subunit of ABC (16), colored by propensity to form amyloid, with red being the highest and blue the lowest propensity. The segment from residue 90 to 100, termed K11V, forms the cylindrin. ]] | [[Image:Rosetta_image.jpg | thumb | 300px | right | Fig. 1 : Ribbon diagram of a single subunit of ABC (16), colored by propensity to form amyloid, with red being the highest and blue the lowest propensity. The segment from residue 90 to 100, termed K11V, forms the cylindrin. ]] | ||
