5vr1: Difference between revisions
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==Structure of a Turripeptide from Unedogemmula bisaya venom== | |||
<StructureSection load='5vr1' size='340' side='right' caption='[[5vr1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5vr1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VR1 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vr1 OCA], [http://pdbe.org/5vr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5vr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vr1 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The turripeptide ubi3a was isolated from the venom of the marine gastropod Unedogemmula bisaya, family Turridae, by bioassay-guided purification; both native and synthetic ubi3a elicited prolonged tremors when injected intracranially into mice. The sequence of the peptide, DCCOCOAGAVRCRFACC-NH2 (O = 4-hydroxyproline) follows the framework III pattern for cysteines (CC-C-C-CC) in the M-superfamily of conopeptides. The three-dimensional structure determined by NMR spectroscopy indicated a disulfide connectivity that is not found in conopeptides with the cysteine framework III: C1-C4, C2-C6, C3-C5. The peptide inhibited the activity of the alpha9alpha10 nicotinic acetylcholine receptor with relatively low affinity (IC50, 10.2 muM). Initial Constellation Pharmacology data revealed an excitatory activity of ubi3a on a specific subset of mouse dorsal root ganglion neurons. | |||
Structure and Biological Activity of a Turripeptide from Unedogemmula bisaya Venom.,Omaga CA, Carpio LD, Imperial JS, Daly NL, Gajewiak J, Flores MS, Espino SS, Christensen S, Filchakova OM, Lopez-Vera E, Raghuraman S, Olivera BM, Concepcion GP Biochemistry. 2017 Nov 14;56(45):6051-6060. doi: 10.1021/acs.biochem.7b00485., Epub 2017 Nov 1. PMID:29090914<ref>PMID:29090914</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Imperial, J | <div class="pdbe-citations 5vr1" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Daly, N L]] | |||
[[Category: Imperial, J S]] | |||
[[Category: Unknown function]] | |||
Revision as of 07:32, 15 November 2017
Structure of a Turripeptide from Unedogemmula bisaya venom
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