5opt: Difference between revisions
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The | ==Structure of KSRP in context of Trypanosoma cruzi 40S== | ||
<StructureSection load='5opt' size='340' side='right' caption='[[5opt]], [[Resolution|resolution]] 4.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5opt]] is a 35 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OPT FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5opt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5opt OCA], [http://pdbe.org/5opt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5opt RCSB], [http://www.ebi.ac.uk/pdbsum/5opt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5opt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q4CQ63_TRYCC Q4CQ63_TRYCC]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.[HAMAP-Rule:MF_03015] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized. Here, we present the near-atomic cryoelectron microscopy structure of a novel bona fide kinetoplastid-specific ribosomal (r-) protein (KSRP) bound to the ribosome. KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. KSRP also interacts with the r-protein eS6 at a region that is only conserved in kinetoplastids. The kinetoplastid-specific ribosomal environment of KSRP provides a promising target for the design of safer anti-kinetoplastidian drugs. | |||
The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein.,Brito Querido J, Mancera-Martinez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y Structure. 2017 Oct 13. pii: S0969-2126(17)30305-2. doi:, 10.1016/j.str.2017.09.014. PMID:29107485<ref>PMID:29107485</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 5opt" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bochler, A]] | |||
[[Category: Chicher, J]] | [[Category: Chicher, J]] | ||
[[Category: Hashem, Y]] | [[Category: Hashem, Y]] | ||
[[Category: Mancera-Martinez, E]] | [[Category: Mancera-Martinez, E]] | ||
[[Category: Querido, J Brito]] | |||
[[Category: Simonetti, A]] | [[Category: Simonetti, A]] | ||
[[Category: Vicens, Q]] | |||
[[Category: Cryo-em]] | |||
[[Category: Kinetoplastid]] | |||
[[Category: Ksrp]] | |||
[[Category: Ribosome]] | |||
Revision as of 07:33, 15 November 2017
Structure of KSRP in context of Trypanosoma cruzi 40S
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