5vx2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vx2 is ~~ON HOLD~~ ~~until Paper Publication~~

==Mcl-1 in complex with Bim-h3Pc-RT==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vx2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX2 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX2 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=9R1:'>9R1</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx2 OCA], [http://pdbe.org/5vx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx2 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx2 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Brouwer, J M]]

[[Category: Colman, P M]]

[[Category: Cowan, A D]]

[[Category: Czabotar, P E]]

[[Category: Apoptosis]]

[[Category: Bcl-2 family]]

[[Category: Pro-surivial]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vx2 is ON HOLD  until Paper Publication
+==Mcl-1 in complex with Bim-h3Pc-RT==
+<StructureSection load='5vx2' size='340' side='right' caption='[[5vx2]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vx2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=9R1:'>9R1</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx2 OCA], [http://pdbe.org/5vx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx2 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Brouwer, J M]]
+[[Category: Colman, P M]]
+[[Category: Cowan, A D]]
+[[Category: Czabotar, P E]]
+[[Category: Apoptosis]]
+[[Category: Bcl-2 family]]
+[[Category: Pro-surivial]]