5yi4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5yi4 is ~~ON HOLD until Paper Publication~~

==Solution Structure of the DISC1/Ndel1 complex==

~~Authors~~: Ye, F., Yu, C., Yu, C.~~, Zhang, M~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5yi4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YI4 FirstGlance]. <br>

~~Description~~: ~~Solution Structure~~ of the ~~DISC1~~/~~Ndel1 complex~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yi4 OCA], [http://pdbe.org/5yi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yi4 RCSB], [http://www.ebi.ac.uk/pdbsum/5yi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yi4 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DISC1_MOUSE DISC1_MOUSE]] Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.<ref>PMID:17825401</ref> <ref>PMID:19303846</ref> <ref>PMID:19502360</ref> <ref>PMID:19778506</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Ye, F]]

[[Category: Yu, C]]

[[Category: Zhang, M]]

[[Category: ~~Yu, C~~]]

[[Category: Coiled coil]]

[[Category: ~~Ye, F~~]]

[[Category: Disc1]]

[[Category: Ndel1]]

[[Category: Protein binding]]

[[Category: Psychiatric disorder]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yi4 is ON HOLD  until Paper Publication
+==Solution Structure of the DISC1/Ndel1 complex==
+<StructureSection load='5yi4' size='340' side='right' caption='[[5yi4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-Authors: Ye, F., Yu, C., Yu, C., Zhang, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yi4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YI4 FirstGlance]. <br>
-Description: Solution Structure of the DISC1/Ndel1 complex
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yi4 OCA], [http://pdbe.org/5yi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yi4 RCSB], [http://www.ebi.ac.uk/pdbsum/5yi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yi4 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DISC1_MOUSE DISC1_MOUSE]] Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.<ref>PMID:17825401</ref> <ref>PMID:19303846</ref> <ref>PMID:19502360</ref> <ref>PMID:19778506</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ye, F]]
+[[Category: Yu, C]]
 [[Category: Zhang, M]]
-[[Category: Yu, C]]
+[[Category: Coiled coil]]
-[[Category: Ye, F]]
+[[Category: Disc1]]
+[[Category: Ndel1]]
+[[Category: Protein binding]]
+[[Category: Psychiatric disorder]]