5mf4: Difference between revisions
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==Tubulin-Dictyostatin complex== | |||
<StructureSection load='5mf4' size='340' side='right' caption='[[5mf4]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5mf4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MF4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7LZ:(3~{Z},5~{E},7~{R},8~{S},10~{S},11~{Z},13~{S},14~{R},15~{S},17~{S},20~{R},21~{S},22~{S})-22-[(2~{S},3~{Z})-hexa-3,5-dien-2-yl]-7,13,15,17,21-pentamethyl-8,10,14,20-tetrakis(oxidanyl)-1-oxacyclodocosa-3,5,11-trien-2-one'>7LZ</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5lxt|5lxt]], [[5lxs|5lxs]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mf4 OCA], [http://pdbe.org/5mf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mf4 RCSB], [http://www.ebi.ac.uk/pdbsum/5mf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mf4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Buffalo rat]] | |||
[[Category: Chick]] | |||
[[Category: Barasoain, I]] | |||
[[Category: Bargsten, K]] | |||
[[Category: Diaz, J F]] | |||
[[Category: Gago, F]] | |||
[[Category: Gardner, N M]] | |||
[[Category: Gomez-Rubio, E]] | [[Category: Gomez-Rubio, E]] | ||
[[Category: | [[Category: Meyer, A]] | ||
[[Category: | [[Category: Naylor, G J]] | ||
[[Category: Nogales, A]] | [[Category: Nogales, A]] | ||
[[Category: Paterson, I]] | |||
[[Category: Prota, A E]] | |||
[[Category: Redondo-Horcajo, M]] | [[Category: Redondo-Horcajo, M]] | ||
[[Category: | [[Category: Sanchez-Murcia, P A]] | ||
[[Category: | [[Category: Steinmetz, M O]] | ||
[[Category: Trigili, C]] | [[Category: Trigili, C]] | ||
[[Category: | [[Category: Cell cycle]] | ||
[[Category: | [[Category: Cytoskeleton]] | ||
[[Category: | [[Category: Microtubule]] | ||
[[Category: | [[Category: Tubulin fold]] | ||
