5i8d: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5i8d is ~~ON HOLD~~ ~~until Aug 18 2018~~

==Crystal Structure of Mouse Cadherin-23 EC19-21 S2064P==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5i8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I8D OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I8D FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">Cdh23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i8d OCA], [http://pdbe.org/5i8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i8d RCSB], [http://www.ebi.ac.uk/pdbsum/5i8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i8d ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.

== Function ==

[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Lk3 transgenic mice]]

[[Category: Jaiganesh, A]]

[[Category: Sotomayor, M]]

[[Category: Adhesion]]

[[Category: Calcium-binding protein]]

[[Category: Cell adhesion]]

[[Category: Hearing]]

[[Category: Mechanotransduction]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5i8d is ON HOLD  until Aug 18 2018
+==Crystal Structure of Mouse Cadherin-23 EC19-21 S2064P==
+<StructureSection load='5i8d' size='340' side='right' caption='[[5i8d]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5i8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I8D FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cdh23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i8d OCA], [http://pdbe.org/5i8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i8d RCSB], [http://www.ebi.ac.uk/pdbsum/5i8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i8d ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Defects in Cdh23 are the cause of waltzer (v) phenotype. Waltzer mice are characterized by deafness and vestibular dysfunction due to degeneration of the neuroepithelium within the inner ear.
+== Function ==
+[[http://www.uniprot.org/uniprot/CAD23_MOUSE CAD23_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.<ref>PMID:11138008</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lk3 transgenic mice]]
+[[Category: Jaiganesh, A]]
+[[Category: Sotomayor, M]]
+[[Category: Adhesion]]
+[[Category: Calcium-binding protein]]
+[[Category: Cell adhesion]]
+[[Category: Hearing]]
+[[Category: Mechanotransduction]]