2ate: Difference between revisions
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|PDB= 2ate |SIZE=350|CAPTION= <scene name='initialview01'>2ate</scene>, resolution 1.80Å | |PDB= 2ate |SIZE=350|CAPTION= <scene name='initialview01'>2ate</scene>, resolution 1.80Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=NIA:((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE'>NIA</scene> | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NIA:((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL+DIHYDROGEN+PHOSPHATE'>NIA</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] </span> | ||
|GENE= purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | |GENE= purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ate FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ate OCA], [http://www.ebi.ac.uk/pdbsum/2ate PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ate RCSB]</span> | |||
}} | }} | ||
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[[Category: Stubbe, J.]] | [[Category: Stubbe, J.]] | ||
[[Category: Zaugg, J B.]] | [[Category: Zaugg, J B.]] | ||
[[Category: nitroair complex]] | [[Category: nitroair complex]] | ||
[[Category: pure]] | [[Category: pure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:57:02 2008'' | ||
Revision as of 22:57, 30 March 2008
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| 2ate, resolution 1.80Å | |||||||||||||
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| Ligands: | MSE, NIA | ||||||||||||
| Gene: | purE (Escherichia coli) | ||||||||||||
| Activity: | Phosphoribosylaminoimidazole carboxylase, with EC number 4.1.1.21 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of the complex of PurE with NitroAIR
Overview
Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.
About this Structure
2ATE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Modular evolution of the purine biosynthetic pathway., Kappock TJ, Ealick SE, Stubbe J, Curr Opin Chem Biol. 2000 Oct;4(5):567-72. PMID:11006546
Page seeded by OCA on Mon Mar 31 01:57:02 2008
