5mav: Difference between revisions
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==Crystal structure of human PCNA in complex with PARG (poly(ADP-ribose) glycohydrolase) peptide.== | |||
<StructureSection load='5mav' size='340' side='right' caption='[[5mav]], [[Resolution|resolution]] 2.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5mav]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MAV FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PCNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mav OCA], [http://pdbe.org/5mav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mav RCSB], [http://www.ebi.ac.uk/pdbsum/5mav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mav ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
[[Category: Djinovic-Carugo, K]] | [[Category: Djinovic-Carugo, K]] | ||
[[Category: Grishkovskaya, I]] | [[Category: Grishkovskaya, I]] | ||
[[Category: Slade, D]] | [[Category: Slade, D]] | ||
[[Category: Interaction]] | |||
[[Category: Parg]] | |||
[[Category: Pcna]] | |||
[[Category: Transcription]] | |||
Revision as of 01:43, 16 November 2017
Crystal structure of human PCNA in complex with PARG (poly(ADP-ribose) glycohydrolase) peptide.
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