5ngn: Difference between revisions
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==Lybatide 2, a cystine-rich peptide from Lycium barbarum== | |||
<StructureSection load='5ngn' size='340' side='right' caption='[[5ngn]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ngn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NGN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ngn OCA], [http://pdbe.org/5ngn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ngn RCSB], [http://www.ebi.ac.uk/pdbsum/5ngn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ngn ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Cysteine-rich peptides (CRPs) of 2-6 kDa are generally thermally and proteolytically stable because of their multiple cross-bracing disulfide bonds. Here, we report the discovery and characterization of two novel cystine-stapled CRPs, designated lybatide 1 and 2 (lyba1 and lyba2), from the cortex of Lycium barbarum root. Lybatides, 32 to 33 amino acids in length, are hyperstable and display a novel disulfide connectivity with a cysteine motif of C-C-C-C-CC-CC which contains two pairs of adjacent cysteines (-CC-CC). X-ray structure analysis revealed the presence of a single cystine-stabilized (alpha + pi)-helix in lyba2, a rare feature of CRPs. Together, our results suggest that lybatides, one of the smallest four-disulfide-constrained plant CRPs, is a new family of CRPs. Additionally, this study provides new insights into the molecular diversity of plant cysteine-rich peptides and the unusual lybatide scaffold could be developed as a useful template for peptide engineering and therapeutic development. | |||
Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold.,Tan WL, Wong KH, Lei J, Sakai N, Tan HW, Hilgenfeld R, Tam JP Sci Rep. 2017 Jul 12;7(1):5194. doi: 10.1038/s41598-017-05037-1. PMID:28701689<ref>PMID:28701689</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5ngn" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lycium barbarum]] | |||
[[Category: Hilgenfeld, R]] | [[Category: Hilgenfeld, R]] | ||
[[Category: Lei, J]] | |||
[[Category: Sakai, N]] | [[Category: Sakai, N]] | ||
[[Category: Tan, W | [[Category: Tan, W L]] | ||
[[Category: | [[Category: Cysteine-rich peptide]] | ||
[[Category: Disulfide bond]] | |||
[[Category: Pi-helix]] | |||
[[Category: Plant protein]] | |||
[[Category: Wolfberry]] | |||
Revision as of 04:43, 16 November 2017
Lybatide 2, a cystine-rich peptide from Lycium barbarum
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