5uvx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5uvx is ~~ON HOLD until Feb 20 2019~~

==BRD4 Bromodomain 2 with A-1359643==

~~Authors~~: ~~Park~~, C.H.

== Structural highlights ==

<table><tr><td colspan='2'>[[5uvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVX OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UVX FirstGlance].

~~Description~~: BRD4 ~~Bromodomain 2~~ with A-~~1359643~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=8NM:N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]methanesulfonamide'>8NM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

[[Category: Park, C.H]]

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvx OCA], [http://pdbe.org/5uvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uvx RCSB], [http://www.ebi.ac.uk/pdbsum/5uvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvx ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: Park, C H]]

[[Category: Helix bundle]]

[[Category: Signaling protein-inhibitor complex]]

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-'''Unreleased structure'''
-The entry 5uvx is ON HOLD  until Feb 20 2019
+==BRD4 Bromodomain 2 with A-1359643==
+<StructureSection load='5uvx' size='340' side='right' caption='[[5uvx]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-Authors: Park, C.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UVX FirstGlance]. <br>
-Description: BRD4 Bromodomain 2 with A-1359643
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NM:N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]methanesulfonamide'>8NM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uvs|5uvs]], [[5uvu|5uvu]], [[5uvt|5uvt]], [[5uvv|5uvv]], [[5uvz|5uvz]], [[5uvy|5uvy]], [[5uvw|5uvw]]</td></tr>
-[[Category: Park, C.H]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvx OCA], [http://pdbe.org/5uvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uvx RCSB], [http://www.ebi.ac.uk/pdbsum/5uvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvx ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Park, C H]]
+[[Category: Helix bundle]]
+[[Category: Signaling protein-inhibitor complex]]