Apoptotic protease-activating factor

spinqualitylabelsall models Human apoptosis protease-activating factor-1 (grey) complex with cytochrome c (red) and caspase 9 (pale blue) forming the apoptosome (PDB entry 5juy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Apoptosis protease-activating factor-1 (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells. Disease Inactivation of Apaf-1 is implicated in disease progression and chemoresistance of some malignancies. Structural highlights Apaf-1 contains several copies of the WD-40 domain which are involved in binding to cytochrome c., caspase recruitment domain (CARD) and an ATPase domain.

3D structures of apoptosis protease-activating factor-1

Updated on 19-November-2017

2ygs, 1cy5, 2p1h – hAPAF-1 CARD domain – human
1c15, 1cww – hAPAF-1 CARD domain – NMR
1z6t – hAPAF-1 + ADP
3ygs – hAPAF-1 CARD domain + procaspase 9
4rhw, 5wvc – hAPAF-1 CARD domain + caspase 9
3j2t, 3jbt – hAPAF-1 + cytochrome c
5juy, 5wve – hAPAF-1 + caspase 9 + cytochrome c

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Michal Harel, Alexander Berchansky, Joel L. Sussman