5n6c: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5n6c ~~is ON HOLD until Paper Publication~~

==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate==

~~Authors~~: ~~Unterlass, J~~.~~E., Basle, A~~.~~, Tucker, J~~.~~, Cano, C~~.~~, Noble, M~~.E.M.~~, Curtin, N~~.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5n6c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6C OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6C FirstGlance].

~~Description~~: ~~Crystal structure of human 3~~-~~phosphoglycerate dehydrogenase in complex with~~ NAD ~~and~~ L-~~Tartrate~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures]~~]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </td></tr>

[[~~Category~~: ~~Curtin~~, N.J]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6c OCA], [http://pdbe.org/5n6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6c RCSB], [http://www.ebi.ac.uk/pdbsum/5n6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6c ProSAT]</td></tr>

[[~~Category~~: ~~Noble, M~~.E.M]]

</table>

[[Category: ~~Unterlass, J.E~~]]

== Disease ==

[[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.

__TOC__

</StructureSection>

[[Category: Phosphoglycerate dehydrogenase]]

[[Category: Basle, A]]

[[Category: Cano, C]]

[[Category: Curtin, N J]]

[[Category: Noble, M E.M]]

[[Category: Tucker, J]]

[[Category: ~~Cano~~, C]]

[[Category: Unterlass, J E]]

[[Category: Dehydrogenase]]

[[Category: Enzymology]]

[[Category: Oxidoreductase]]

[[Category: Serine metabolism]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5n6c is ON HOLD  until Paper Publication
+==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate==
+<StructureSection load='5n6c' size='340' side='right' caption='[[5n6c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Unterlass, J.E., Basle, A., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5n6c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6C FirstGlance]. <br>
-Description: Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </span></td></tr>
-[[Category: Curtin, N.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6c OCA], [http://pdbe.org/5n6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6c RCSB], [http://www.ebi.ac.uk/pdbsum/5n6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6c ProSAT]</span></td></tr>
-[[Category: Noble, M.E.M]]
+</table>
-[[Category: Unterlass, J.E]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.
+__TOC__
+</StructureSection>
+[[Category: Phosphoglycerate dehydrogenase]]
 [[Category: Basle, A]]
+[[Category: Cano, C]]
+[[Category: Curtin, N J]]
+[[Category: Noble, M E.M]]
 [[Category: Tucker, J]]
-[[Category: Cano, C]]
+[[Category: Unterlass, J E]]
+[[Category: Dehydrogenase]]
+[[Category: Enzymology]]
+[[Category: Oxidoreductase]]
+[[Category: Serine metabolism]]