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| <StructureSection load='5kud' size='350' side='right' caption='Structure of UMP/CMP kinase complex with SDP and CMP (PDB entry [[5kud]])' scene=''> | | <StructureSection load='5ukd' size='350' side='right' caption='Structure of UMP/CMP kinase complex with ADP and CMP (PDB entry [[5ukd]])' scene=''> |
| __TOC__ | | __TOC__ |
| == Function == | | == Function == |
Revision as of 11:11, 23 November 2017
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Function
UMP/CMP kinase (UCK) or uridylmonophosphate/cytidylmonophosphate kinase phosphorylates UMP, CMP and deoxy-CMP[1].
Relevance
everal cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK[2].
Structural highlights
- ↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
- ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132
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3D Structures of UMP/CMP kinase
Updated on 23-November-2017
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor
1tev – UCK – human
References
