5lbw: Difference between revisions
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==Structure of the human quinone reductase 2 (NQO2) in complex with volitinib== | |||
<StructureSection load='5lbw' size='340' side='right' caption='[[5lbw]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5lbw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LBW FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=V0L:volitinib'>V0L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.5.1 1.10.5.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lbw OCA], [http://pdbe.org/5lbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lbw RCSB], [http://www.ebi.ac.uk/pdbsum/5lbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lbw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kuester, B]] | |||
[[Category: Medard, G]] | [[Category: Medard, G]] | ||
[[Category: Schneider, S]] | [[Category: Schneider, S]] | ||
[[Category: | [[Category: Kinase inhibitor]] | ||
[[Category: Oxidoreductase]] | |||
[[Category: Quinone reductase 2]] | |||
[[Category: Ribosyldihydronicotinamide dehydrogenase]] | |||
[[Category: Volitinib]] | |||
