5lo6: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5lo6" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==HSP90 WITH indazole derivative== | |||
<StructureSection load='5lo6' size='340' side='right' caption='[[5lo6]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5lo6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LO6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=70O:3-(3,3-dimethylbutyl)-~{N}-methyl-~{N}-[4-(1-methylpiperidin-4-yl)phenyl]-6-oxidanyl-2~{H}-indazole-5-carboxamide'>70O</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lo6 OCA], [http://pdbe.org/5lo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lo6 RCSB], [http://www.ebi.ac.uk/pdbsum/5lo6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lo6 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Amaral, M]] | |||
[[Category: Graedler, U]] | [[Category: Graedler, U]] | ||
[[Category: | [[Category: Chaperone]] | ||
